Quantification of NADPH balance during adipogenesis

نویسندگان

  • Ling Liu
  • Supriya Shah
  • Jing Fan
  • Kathryn Wellen
  • Joshua Rabinowitz
چکیده

Background NADPH provides reducing power for macromolecule synthesis and antioxidant defense. The pathways used to make NADPH under different physiological circumstances remain unclear. In growing cells, much NADPH production is coupled to nucleotide synthesis via the oxidative pentose phosphate and folate pathways. Here we examine, using isotope tracers and flux analysis, NADPH production routes in adipocytes.

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عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2014